Study on Clinical Application of Detection of T-cell Receptor Gene Rearrangement in Cutaneous T-cell Lymphoma
- VernacularTitle:T细胞受体基因重排检测皮肤 T 细胞淋巴瘤
- Author:
Chunlei ZHANG
;
Encong GONG
;
Yongsheng LIU
;
- Publication Type:Journal Article
- Keywords:
Cutaneous T-cell Lymphoma;
T-cell receptor;
PCR
- From:
Chinese Journal of Dermatology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the clinical application of molecular diagnosis in cutaneous T-cell lymphoma (CTCL),the polymerase chain reaction Was used to detect the rearrangements of T-cell receptor (TCR)gene in 60 patients with cutaneous lymphocytic infiltrates.The result showed that dominant clonal TCR-? or ? gene rearrangements were detected in 36/40 CTCL,4/6 suspected mycosis fun- goldes/S?zary syndrome,1/1 lymphomatoid papulosis.No dominant clonal TCR-? or ? gene rearrange- ments were detected in 2 patients with CBCL,1 patient with lymphocytoma cutis,8 patient with benign lymphocytic infiltrates of skin and 2 normal controls.This study demonstrates that the method is help- ful for the lineage determination,clonality and early diagnosis of CTCL.
