EXPERIMENTAL STUDY OF COMBINATION TREATMENT WITH SODIUM MORRHUATE AND CIS-DIAMINOCHLOROPLATINUM FOR HUMAN GASTRIC CANCER
- VernacularTitle:顺铂鱼肝油酸钠配伍治疗胃癌的实验研究
- Author:
Peng HOU
;
Zenghua LI
;
Caifu XU
;
- Publication Type:Journal Article
- Keywords:
Gastric cancer MTT Nude mice Cis-diaminodichloroplatinum Sodium norrhuate
- From:
Chinese Journal of Digestive Endoscopy
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The antitumor effect of sodium morrhuate (SM ) and cis - diaminoaichloroplatinum (CDDP ) for gastric cancer cell SGC - 7901 in vitro is observed with MTT assay. Human gastric cancer cells line SGC - 7901 were inoculated subcutaneously in the naked mice , so xenografts were established. The tumor of the mice in the combination groups were cross injected with SM 50mg . kg~(-1) . time~(-1) , 50?l and CDDP ( 3mg ? kg~(-1)? time~(-), 50?l)in varying order at an interval of 30 minutes. In each mouse the tumors were injected every third davs for a total of three injections. lt was found SM had strong antitumor effect on gastric can- cer cells in vitro experiment. The antitumor effect of local injection in combination groups were much stronger than that in any other single drug groups. The histopathological section observation showed that all tumors cells were necrotic in combination groups, There could be seen fibrous histocysts around the . necrotic tumor tissue in observation groups , and necrotic vascular endotheliocytes. The experiment showed that combined injection with SM and CDDP had a synergic antitumor effect.
