Study of P53 in Cutaneous Squamous Epithelial Cell Tumour
- VernacularTitle:皮肤鳞状上皮细胞肿瘤中p53蛋白的表达
- Author:
Dongxia LI
;
Ping TU
;
Shengqing MA
- Publication Type:Journal Article
- Keywords:
p53;
Mutation;
Cutaneous;
Tumour
- From:
Chinese Journal of Dermatology
1995;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Gene mutation is known to play an important role in carcinogenesis.There are two types of p53 gene,wild-type and mutant-type.In order to observe the relationship between p53 gene mutation and cutaneous squarnous epithelial ceil tumours,immunohistochemical study was carried out for p53 ex- pression in the epidermis from 29 patients with cutaneous squamous epithelial cell tumouts using a new immunohistochemical technique labelled streptavidin biotin system.The results showed that p53 positive staining was only confined to areas of atypical proliferation of epithelia in 3/6 cases of actinic keratosis. 6/10 cases of Bowen's disease and 8/13 cases of squamous cell carcinoma showed that p53 positive staining was seen throughout the tumour.It is suggested that p53 gene mutation might play an impor- tant role in cutaneous squamous epithlial cell tumour formation.
