Expression of HLA class Ⅱ antigens, interleukin-2 receptors and transferrin receptors of monocytes from patients with insulindependent diabetes mellitus
- VernacularTitle:胰岛素依赖型糖尿病患者外周血单核细胞膜表面HLA-Ⅱ类抗原、白细胞介素2受体和铁传递蛋白受体的表达
- Author:
Zheng-Kuan MAO
;
Zhixin JIN
;
Bingyang SHAO
;
Xin-Wei FENG
;
Feili GONG
;
Yong XU
;
Ping XIONG
;
Liangru SHI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, insulin-dependent;
Monocytes;
HLA-Ⅱ antigens;
Receptor, interleukin-2;
Receptors, transferrin
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Expression of HLA class Ⅱ antigens(HLA-DR, DQ and DP), interleukin2 receptors(IL-2R) and transferrin receptors(TfR) of blood monocytes from 10 patients with insulin-dependent diabetes meIlitus (IDDM) were assayed with the indirect immune fluorescence technique using corresponding monoclonal antibodies and the FITC-labelled second antibody. The results showed that the number of HLA-DQ~+ monocytes was much more in diabetics than in normal controls. The percentages of HLA-DR~+ and HLA-DP~+ monocytes in diabetics were not different significantly from those in normal controls. Besides, IL-2R~+ and TfR~+ monocytes were also found to be very much increased in diabetics as compared with controls. It was possible that increased expression of HLA-DQ antigen, IL-2R and TfR of monocytes in patients with IDDM might play a role in the pathogenesis of the autoimmune reaction.
