The damage of rat brain mitochondria induced by endotoxin and its relation to oxygen free radical metabolism
- VernacularTitle:内毒素对大鼠脑线粒体的损伤及与氧自由基的关系
- Author:
Lang DING
;
Xiawen WANG
;
- Publication Type:Journal Article
- Keywords:
Brain;
Mitochondria;
Endotoxins;
Lipid peroxides;
Superoxide dismutase;
Glutathione peroxidase;
Succinate dehydrogenase
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The study was undertaken to determine whether low dose of endotoxin could induce rat brain damage, and its relation to the metabolism of oxygen free radicals. Male Wistar rats were treated with E. Coli endotoxin intraperitoneally (2 mg/kg body wt). Fourteen hours later, the lipoperoxide level was markedly elevated in animals given endotoxin compared with that in the controls (5.0?1.0 vs 3.9?0.7, P
