A Scanning Electron Microscopic Study on a Rabbit Model with Acute Renal Failure Caused by Glycerol
- VernacularTitle:家兔急性肾衰时肾脏的扫描电镜观察
- Author:
Buzhen ZHANG
;
- Publication Type:Journal Article
- Keywords:
Acute renal failure;
Scanning electron microscopy;
Rabbit;
Glycerol
- From:
Journal of Kunming Medical University
1990;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Acute renal failure was inflicted on 38 rabbits with the subcutaneous injection of 50 per cent glycerin solution 15ml/kg.The renal pathologic changes in the rabbits were observed by using scanning electron microscopy from 1 to 72 hours after the injection of glycerin.The re- sults showed:in the initial phase,both the glomerular endothelium and epithelium changed pathologically and there was fibrin formation in the renal microvascularity.The glomerular endothelium and epithelium were covered by dense amorphous particulate matter through the initial and maintain phase of the acute renal failure.The renal tubules were obstructed by casts,and the tubule rupture was found in the maintain phase.These findings suggested that early in the course of the disease the affects of glomerular changes and accumulation of for- eign matter might be more important than the renal tubule for the pathogenesis of glycerol-induced acute renal failure in rabbits.
