Studies on the activation of oncogenes by alternariol in human fetal esophageal epithelium
- VernacularTitle:交链孢酚激活人胎食管上皮组织细胞癌基因的研究
- Author:
Peng ZHANG
;
Zi-Ming DONG
;
Huiling HAO
;
Guiting LIU
;
Yingzhong ZHEN
;
Jian MIAO
;
Xiaoxing CUI
;
Wanwan LIANG
;
Shixin LU
- Publication Type:Journal Article
- Keywords:
Alternaria;
Oncogenes;
Mycotoxins;
Carcinogens;
Esophageal neoplasms
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
This paper reported that the activation of oncogenes in human fetal esopha geal epithelium treated by alternariol (AOH). It was found that NIH/3T3 cells were transformed via transfeetion of DNA extracted from human fetal esophageal epithelium which was cultured and treated by 10?g/ml AOH in a short term in vitro. The efficiency of primary loci was 0.17 focus per ?g of DNA. In the secondary transfection, the efficiency was 0.58 focus per ?g of DNA (P
