Effects of Panax Notoginseng Saponins Enteric-coated Pellets on Hemorheology in Rabbits
- VernacularTitle:三七总皂苷肠溶微丸对高脂血症家兔血液流变学的影响
- Author:
Shihua LU
;
Lili WU
;
Huagang LIU
;
Ming CHEN
;
Yan'e QIN
;
Xingzhen HUANG
;
- Keywords:
Panax notoginseng saponins enteric-coated pellets;
Hemorheology;
Whole-blood viscosity;
Plasma viscosity
- From:
China Pharmacist
2017;20(4):658-660
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the effects of panax notoginseng saponins (PNS) enteric-coated pellets on hemorrheology in rabbits.Methods:The rabbits were divided into the normal control group,the model control group,Xueshuangtong injection (lyophilization) group(15 mg·kg-1·d-1 ,im),PNS enteric-coated pellets groups respectively at high(45 mg·kg-1·d-1,ig),medium(30 mg·kg-1·d-1,ig) and low (15 mg·kg-1·d-1,ig) dose.The model was established by intragastric administration of high-fat diet.The whole-blood viscosity,plasma viscosity,erythrocyte aggregational index,crythrocyte index of rigidity and erythrocyte electro-phoresis rate in the groups were detected using hemorheological methods.Results:The above indices of hemorheology in the model control group were all significantly higher than those in the normal control group (P<0.01),suggesting the successful establishment of the model.Compared with the model control group,PNS enteric-coated pellets at high and medium doses could significantly reduce the whole blood viscosity and plasma viscosity(P<0.01 or P<0.05);PNS enteric-coated pellets group at low dose could significantly reduce the whole blood middle shear viscosity and plasma viscosity(P<0.05);the three PNS enteric-coated pellets groups could significantly reduce the agglutination index(P<0.01);PNS enteric-coated pellets at high and medium doses could significantly reduce the crythrocyte index of rigidity(P<0.01 or P<0.05);the three PNS enteric-coated pellets groups could significantly reduce the erythrocyte electro-phoresis rate,while there was no significant difference(P>0.05).Compared with Xueshuangtong injection (lyophilization) group,PNS enteric-coated pellets group at medium dose could significantly reduce the whole blood middle shear viscosity(P<0.05).Conclusion:PNS enteric-coated pellets can reduce the whole-blood viscosity,plasma viscosity,erythrocyte aggregational index,crythrocyte index of rigidity and erythrocyte electro-phoresis rate,and effectively promote blood circulation and remove stasis,inhibit thrombosis formation and increase blood supply for heart and cerebral vessels.
