"Evaluation of the ""Multi-Efficacy of One Drug"" of Traditional Chinese medicines Based on the Biological Target Network: Towards Precision Medicine"
10.11842/wst.2017.01.006
- VernacularTitle:基于生物靶标网络的中药“一药多效”评价与精准用药
- Author:
Ming NIU
;
Cong'en ZHANG
;
Shanna WU
;
Yongshen REN
;
Zhuo SHI
;
Jiabo WANG
;
Xiaohe XIAO
- Keywords:
Traditional Chinese medicines;
multi-efficacy of one drug;
network pharmacology;
metabolomics;
precision medicine
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2017;19(1):44-49
- CountryChina
- Language:Chinese
-
Abstract:
Multi-Efficacy of One Drug (MEOD) refers to the traditional Chinese medicines (TCM) with diverse efficacies.MEOD,one of the important characteristics of TCM,is regarded as the basis of clinical rational drug use.However,there have been few reports on the MEOD research so far.In this paper,with rhubarb selected as a typical model drug,metabolomics and network pharmacology analysis are integrated to investigate the mechanisms of MEOD with the employment of the two animal models of constipation and jaundice.Then,the biological target network of MEOD is established for promoting the precision of the quality control and clinical use of TCM.
