Risk factors for different brain region atrophy among stroke and transient ischemic attack patients
10.3969/j.issn.1002-0152.2016.10.008
- VernacularTitle:卒中及短暂性脑缺血发作患者不同部位脑萎缩的危险因素
- Author:
Jie YANG
;
Tengfei OU
;
Shuxiang PU
;
Longchang XIE
;
Jianrui YIN
;
Yihua HE
;
Xin'guang YANG
;
Haiyan YAO
;
Cong GAO
- Keywords:
Stroke;
Transient ischemic attack;
Brain atrophy
- From:
Chinese Journal of Nervous and Mental Diseases
2016;42(10):609-615
- CountryChina
- Language:Chinese
-
Abstract:
Objectives Brain atrophy plays a key role in post-stroke dementia. The current study aims to explore risk factors for brain atrophy in different regions in order to find the ultimate therapeutic strategy. Methods Consecutive stroke and/or transient ischemic attack (TIA) patients were recruited from July 2012 to June . The clinical features, neuro?imaging findings and risk factors were collected during hospitalization. Logistic regression analysis showed that, except for age, female gender (Odds ratio, OR=2.447, P=0.007) and the number of silent lacuna infarcts (OR=1.414, P=0.027) were independent risk factors for frontal lobe atrophy. Ischemic stroke history (OR=2.224, P=0.024) was the independent risk factor for parietal lobe atrophy. All of extra-/intracranial larger artery diseases (OR=2.584, P=0.015) and white mat?ter severity score (OR=1.112, P=0.007) as well as the number of silent lacuna infarcts (OR=1.158,P=0.042) were inde?pendent risk factors for medial temporal lobe atrophy. Moreover, diabetes (OR=2.109, P=0.001),atrial fibrillation (OR=1.934, P=0.015) and white matter severity score (OR=1.098, P=0.002) were independent risk factors for global brain atro? phy. Conclusion Risk factors for brain atrophy included diabetes,atrial fibrillation, silent lacuna infarcts and white mat?ter changes. We should pay more attention to those patients with above risk factors in order to slow down the progression of brain atrophy and also prevent them from dementia by early interventions.
