The correlations bte ween xe pres ion of tumora ssociated macrophages and the por gnostic signfi icances in triple negative breastc ancer
10.11904/j.issn.1002-3070.2017.010.01
- VernacularTitle:肿瘤相关巨噬细胞在三阴性乳腺癌中的表达与临床病理因素及预后关系的研究
- Author:
Changyan YU
;
Lina ZHEN
;
Hongbing LI
;
Yue ZHANG
;
Qingyuan ZHANG
- Keywords:
Triple negative breast cancer;
Tumor associated macrophages;
Microvessel density;
Prognosis
- From:
Practical Oncology Journal
2017;31(1):1-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significances of expression of tumor associated macrophages ( TAMs) and its correlation with microvessel density ( MVD) in triple negative breast cancer ( TNBC) .Methods Immunohistochemistry was used to detect TAMs and MVD expression in 108 TNBC tissues and to analyze the cor-relation between TAMs with clinicopathological features ,prognosis and MVD.Results The expression of TAMs was correlated with the tumor size,lymph node metastasis,histological grade,TNM stage and MVD,but had no statistically significant association with age .TAMs was correlated with 5 year disease free survival ( DFS) and over-all survival( OS);MVD was correlated with 5 year DFS, while no correlation with OS .Univariate and multivariate analyses showed that TAMs was an independent unfavorable prognostic factor for patients with TNBC .Conclusion High infiltration of TAMs indicated poor survival rate for patients with TNBC .The infiltration of TAMs was a new,important risk factor for TNBC recurrence .TAMs were closely related to MVD ,by promoting tumor angiogen-esis,thereby promoting TNBC growth ,invasion and metastasis ,and further affect the prognosis of patients with TN-BC.
