Effect of splenectomy on hematological and immune system for children with major thalassemia
10.3969/j.issn.1673-4130.2016.18.011
- VernacularTitle:脾切除对珠蛋白生成障碍性贫血患儿血液及免疫系统的影响
- Author:
Jingmei YANG
;
Wenyan CHEN
- Publication Type:Journal Article
- Keywords:
major thalassemia;
splenectomy;
hemoglobin;
immunoglobulin;
complements
- From:
International Journal of Laboratory Medicine
2016;37(18):2534-2536
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of splenectomy on hematological and immune system for children with major thalas‐semia .Methods This retrospective study was performed on 68 children with major thalassemia .The indexes of blood and immune system included white blood cell ,red blood cell ,hemoglobin ,platelet ,immunoglobulin IgG ,IgM and IgA and serum complement C3 , C4 ,which were recorded at pre‐splenectomy ,3 months and 3 -12 months post‐splenectomy .Results The mean age of children in this study was 8 .6 ± 3 .1 years .There were 28 children with α‐thalassemia ,35 with β‐thalassemia and 5 with αβ‐thalassemia .The white blood cell ,red blood cell and platelet count increased significantly both at 3 and 3-12 months post‐splenectomy as compared with pre‐splenectomy .The red blood cell and hemoglobin in children with β‐thalassemia or αβ‐thalassemia were significantly lower than children withα‐thalassemia both at pre and post‐splenectomy .However ,the platelet count were similar .The immunoglobulin IgA and IgM were significantly lower at post‐splenectomy than pre‐splenectomy .However ,the IgG ,C3 and C4 did not decrease sig‐nificantly .Conclusion Splenectomy could increase the hemoglobin level and improve the anemia in children with major thalassemia . However ,it might be harmful to the immune system .
