Clinical significance of HPV E6/E7 mRNA test combining TCT test to detect early cervical dysplasia
10.3969/j.issn.1006-5725.2016.18.031
- VernacularTitle:HPV E6／E7联合液基细胞学检查在宫颈癌前病变筛查中的意义
- Author:
Zuoli XIA
;
Guo-Rong CHEN
;
Dan PAN
;
Pin LIN
;
Ru JIN
;
- Publication Type:Journal Article
- Keywords:
Early cervical dysplasia;
HPV E6/E7 mRNA detection;
Low-grade squamous intraepithelial;
High-grade squamous intraepithelial;
Liquid-based cytology
- From:
The Journal of Practical Medicine
2016;32(18):3053-3056
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of HPV E6/E7 mRNA test combining liquid-based cytology test in cervical cancer screening. Methods A total of 377 samples from Wenzhou People's Hospital from June 2014 to September 2015 were collected and screened by HPV E6/E7 mRNA test combining with liquid-based cytology test , and the results was compared with the findings from the gold criteria of histology and pathology. Results The combination of HPV E6/E7 mRNA test and liquid-based cytology test can enhance the testing sensitivity and specificity. The sensitivity of the combination of HPV E6/E7 mRNA test and liquid-based cytology test for the diagnosis of LSIL was 94.41%, and that for the diagnosis of HSIL was 96.36%. Based on the gold criteria of histology and pathology , the sensitivity , specificity , positive-predictive value and negative predictive value of HPV E6/E7 mRNA test for the diagnosis of HSIL was 90%, 60.67%, 48.53% and 92.49%respectively. The sensitivity, specificity, positive-predictive value and negative- predictive value of liquid-based cytology test for the diagnosis of HSIL was 72.73%, 75.28%, 54.79% and 87.01% respectively. Conclusions The sensitivity of HPV E6/E7 mRNA test is superior to that of liquid-based cytology test , while the specificity of HPV E6/E7 mRNA test is inferior to that of liquid-based cytology test. The negative predictive value of HPV E6/E7 mRNA test is more meaningful than that of liquid-based cytology test. The combination of HPV E6/E7 mRNA test and liquid-based cytology test can enhance the testing sensitivity , but it does not increase the specificity.
