Development and characterization of ethylcellulose based microsphere for sustained release of nifedipine$
- Author:
Parida Patitapabana
;
Mishra Chandra Subash
;
Sahoo Subhashree
;
Behera Ajit
;
Nayak Prasad Bibhukalyan
- Publication Type:Journal Article
- Keywords:
Nifedipine;
Microsphere;
Solvent evaporation;
Sustained release
- From:
Journal of Pharmaceutical Analysis
2015;5(5):341-344
- CountryChina
- Language:Chinese
-
Abstract:
This article introduced the work of ethylcellulose based polymeric microsphere loaded with nifedipine for reduction in frequency of administration with low solubility in aqueous medium and high rate of absorption in the stomach. The non-aqueous polymeric suspension was put dropwise into an aqueous medium containing polyvinyl alcohol as a surfactant for the synthesis of microsphere by solvent eva-poration. The microspheres were characterized by different techniques, namely, XRD, SEM, and NMR. The formation of microspheres was confirmed by SEM. XRD analysis revealed the semi-crystallinity nature of microspheres. The NMR study indicated the presence of hetero-aromatic nucleus in the microsphere.
