Progress of transcription factor ZONAB
10.3760/cma.j.issn.1673-4408.2016.10.013
- VernacularTitle:转录因子ZONAB研究进展
- Author:
A'na HOU
- Publication Type:Journal Article
- Keywords:
ZONAB;
Transcription factor;
Tight junction;
Proliferation;
Differentiation
- From:
International Journal of Pediatrics
2016;43(10):793-796
- CountryChina
- Language:Chinese
-
Abstract:
As a Y-box transcdption factor,ZONAB performs biological functions of promoting the proliferation and inhibiting the differentiation of epithelial cells,regulating the function of tight junctions,as well as promoting the epithelial-mesenchymal transition.ZONAB plays its transcriptional activity by interacting with other tight junction elements and genes,proteins,enzymes and transcription factors which are enrolled in the cell cycle.Meanwhile,its transcriptional activity is also regulated by many other factors.ZONAB takes part in the proliferation,differentiation of epithelial cells,stress reaction,organogenesis and oncogenesis progress,which has been proved to be associated with the genesis and development of many diseases.The regulation mechanism and clinical significance of ZONAB has been the focus at home and abroad.
