Herb drug interaction：effect of Manix? on pharmacokinetic parameters of pefloxacin in rat model
10.12980/APJTB.4.2014C400
- Author:
Odunke Sunday Nduka
;
Eleje Okonta
;
Christiana Chika Abba
;
Peter Chibueze Ihekwereme
;
Uchenna Ekwedigwe
;
Matthew Okonta
- Publication Type:Journal Article
- Keywords:
Pefloxacin;
Manix?;
Bioavailability;
Escherichia coli;
Microbiological assay
- From:Asian Pacific Journal of Tropical Biomedicine
2014;(z1):413-416
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the effect of Manix?, the commonly used polyherbal formulation on pefloxacin pharmacokinetic parameters.Methods:from hospitalized patients.Results:Microbiological assay was employed using clinical isolate of Escherichia coli samples Manix? altered the bioavailability parameters of pefloxacin as thus, maximal concentration (Cmax) of pefloxacin (0.91±0.31) μg/mL occurred at time to reach maximal concentration (tmax) 4.0 h while in the group that received Manix? alongside pefloxacin Cmax was (0.22±0.08) μg/mL at tmax 1.0 h respectively. The area under curve of pefloxacin alone was (7.83±5.14) μg/h/mL while with Manix? was (2.60±0.08) μg/h/mL. There was a significant difference between Cmax, tmax and area under curve between pefloxacin alone and pefloxacin after Manix? pre-treatment (P<0.05).Conclusions:The concurrent use of Manix? and pefloxacin has been found to compromise the therapeutic effectiveness of pefloxacin which could lead to poor clinical outcomes in patients.
