The emergence of drug resistant HIV variants and novel anti-retroviral therapy
10.1016/S2221-1691(13)60106-9
- Author:
Paydary Koosha
;
Khaghani Parisa
;
Emamzadeh-Fard Sahra
;
SeyedAlinaghi SeyedAhmad
;
Baesi Kazem
- Publication Type:Journal Article
- Keywords:
HIV infection;
Evolution;
Drug resistance
- From:Asian Pacific Journal of Tropical Biomedicine
2013;(7):515-522
- CountryChina
- Language:Chinese
-
Abstract:
After its identification in 1980s, HIV has infected more than 30 million people worldwide. In the era of highly active anti-retroviral therapy, anti-retroviral drug resistance results from insufficient anti-retroviral pressure, which may lead to treatment failure. Preliminary studies support the idea that anti-retroviral drug resistance has evolved largely as a result of low-adherence of patients to therapy and extensive use of anti-retroviral drugs in the developed world;however, a highly heterogeneous horde of viral quasi-species are currently circulating in developing nations. Thus, the prioritizing of strategies adopted in such two worlds should be quite different considering the varying anti-retroviral drug resistance prevalence. In this article, we explore differences in anti-retroviral drug resistance patterns between developed and developing countries, as they represent two distinct ecological niches of HIV from an evolutionary standpoint.
