Cardioprotective and hepatoprotective effects ofCitrus hystrix peels extract on rats model
- Author:
Putri Herwandhani
;
Nagadi Standie
;
Larasati Arum Yonika
;
Wulandari Nindi
;
Hermawan Adam
- Publication Type:Journal Article
- Keywords:
Citrus hystrixD.C.;
Cardiohepatoprotector;
Histopathology;
Chemoterapy
- From:Asian Pacific Journal of Tropical Biomedicine
2013;(5):371-375
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the combination effect of doxorubicin andCitrus hystrix(kaffir lime’s) peel ethanolic extract(ChEE) on blood serum alanine aminotransferase(ALT) and aspartate aminotransferase(AST) activity and cardio-hepato-histopathology of femaleSpragueDawley rats. Methods:Doxorubicin andChEE(5 rats per group) were administered in five groups of3 rats each for11 d.GroupI: doxorubicin(dox)4.67 mg/kg body weight;GroupII: dox+ChEE500 mg/kg body weight;GroupIII: dox+ChEE1000 mg/kg body weight;GroupIV:ChEE1000 mg/kg body weight;GroupV: untreated(control).Results:ChEE repaired cardiohistopathology profile of doxorubicin induced cardiotoxicity and hepatotoxicity rats, but did not repair neither hepatohistopathology profile nor reduce serum activity ofALT andAST.Conclusion:ChEE has potency to be developed as cardioprotector agent in chemotherapy.
