Anti-inlfammatory and antipyretic properties of kang 601 heji, a traditional Chinese medicine oral liquid dosage form
- Author:
Alolga Nammahime Raphael
;
Amadi Wambui Sarah
;
Onoja Vitus
;
Assanhou Gabin Assogba
;
Muyaba Moses
;
Kassim Abasse Said
- Publication Type:Journal Article
- Keywords:
Kang 601 heji;
Anti-inflammatory;
Antipyretic;
Model;
Mechanisms
- From:Asian Pacific Journal of Tropical Biomedicine
2015;(11):872-877
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the scientific basis for the use of Kang 601 heji (K-601) as an anti-inflammatory and antipyretic agent using appropriate animal models.
Methods:Carrageenan-induced rat paw and xylene-induced ear oedemas were models used to investigate anti-inflammatory actions of K-601. Lipopolysaccharide-induced pyrexia model was used to evaluate antipyretic activity in Wistar rats. The anti-inflammatory and antipyretic mechanisms were evaluated by detecting prostaglandins E2, nitric oxide, interleukin-1βand tumor necrosis factor-αlevels using appropriate reagents and ELISA kits.
Results:The results revealed that K-601 reduced the level of inflammations in both anti-inflammatory models in a dose-dependent manner. The same was true for the antipyretic model. The possible mechanisms of actions were through the inhibition of prostaglandins E2, interleukin-1β, tumor necrosis factor-αand nitric oxide.
Conclusions: K-601 has proven anti-inflammatory and antipyretic actions. The findings provide a scientific basis for the use of K-601 as anti-inflammatory and antipyretic agent in traditional Chinese medicinal practice.
