Antioxidant and cytotoxic activity of Acanthus ilicifolius flower
- Author:
Firdaus Muhamad
;
Prihanto Awaludin Asep
;
Nurdiani Rahmi
- Publication Type:Journal Article
- Keywords:
Acanthus ilicifolius;
Antioxidant;
Cytotoxic;
Flower
- From:Asian Pacific Journal of Tropical Biomedicine
2013;(1):17-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the antioxidant and cytotoxic activity of the flower of Acanthus ilicifolius (A. ilicifolius). Methods: Antioxidant activity was determined as antiradical efficiency with diphenyl picrylhydrazil (DPPH) method and cytotoxic assay was undertaken using brine shrimp lethal toxicity test. Results: A. ilicifolius flower contained terpenoid, phenolic compounds, and alkaloid. The methanol extract of A. ilicifolius flower showed the highest antiradical efficiency (AE=1.41í10-3) against DPPH radicals and the highest cytotoxicity (LC50=22 μg/mL) against brine shrimp nauplii. Conclusions: It is suggested that active compounds of A. ilicifolius flower solved in methanol play a role to inhibit free radical activity and kill Artemia salina nauplii. The substances can be considered as potential antioxidant and cytotoxic agents as well as imminent candidate for cancer therapy.
