Study on correlation between plasma paliperidone concentration and serum prolactin level
10.3969/j.issn.1673-4130.2016.17.025
- VernacularTitle:帕利哌酮血药浓度与血清泌乳素的相关性研究
- Author:
Shunshun DENG
;
Jiaxuan ZHANG
;
Yongshuang GAO
- Publication Type:Journal Article
- Keywords:
paliperidone;
prolactin;
schizophrene
- From:
International Journal of Laboratory Medicine
2016;37(17):2421-2422
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between plasma paliperidone concentration and serum prolactin level .Meth‐ods The plasma paliperidone concentration and serum prolactin level at the ends of 0 ,1 ,2 ,4 ,6 ,8 weeks after taking paliperidone were separately detected in 49 patients with schizophrene (25 males and 24 females) .Then the statistical analysis was performed .Results The serum prolactin level in the schizophrenic patients had statistically significant difference before and after taking paliperidone(P<0 .05) .The increase of plasma paliperidone concentration could cause the increase of serum prolactin level .Conclusion Inthe application of paliper‐idone for treating schizophrene ,plasma paliperidone concentration and serum prolactin level should be monitored for improving the medication safety and decreasing the adverse drug reactions .
