Association of CD4 + T lymphocyte count with HBV replication and progression of liver diseases in patients infected with HIV and HBV
10.3760/cma.j.issn.1671-7368.2016.06.015
- VernacularTitle:CD4+T淋巴细胞水平对HIV合并HBV感染患者HBV病毒复制及肝病的影响
- Author:
Rongrong YANG
;
Xi'en GUI
;
Yong XIONG
;
Shicheng GAO
;
Yajun YAN
;
- Publication Type:Journal Article
- Keywords:
Human immunodeficiency virus proteins;
Hepatitis B virus;
CD4 positive T-lymphocytes
- From:
Chinese Journal of General Practitioners
2016;15(6):466-468
- CountryChina
- Language:Chinese
-
Abstract:
The clinical data of 459 patients,who were first diagnosed as HIV/HBV co-infection from January 2007 to December 2013,were retrospectively analyzed.Among all patients,there were 89 cases with CD4 ＜ 50/μl,134 cases with CD4 50-200/μl and 236 cases with CD4 ＞ 200/μl,when HIV infection was diagnosed.In these three groups with different CD4 levels,the HBV DNA positive rates were 49.3％ (37/75),50.5％ (54/107) and 33.7％ (66/196);the HBV viral load were (6.37 ± 1.71) log10 copies/ml,(5.82 ± 1.86) log10 copies/ml and (4.36 ± 1.64) log10 copies/ml;the rates of abnormal liver function were 29.2％ (26/89),29.1％ (39/134) and 10.6％ (25/236);the occurrence rates of end-stage-liver-diseases were 16.9％ (15/89),14.9％ (20/134) and 5.1％ (12/236);the mortality rates were 10.1％ (9/89),9.7％ (13/134) and 3.8％ (9/236),respectively.The HBV DNA positive rates,HBV viral load,the rates of abnormal liver function,the occurrence rates of end-stage-liver-diseases and the mortality rates in CD4 ＞ 200/μl group were lower than that in CD4 ＜ 50/μl group and 50-200/μl group.The results suggest that for HIV and HBV co-infection patients,HBV replication level and prognosis of liver diseases are associated with CD4 + T lymphocyte count.
