Imatinib mesylate therapy for patients with chronic myeloid leukemia:long-term out-come from a single center in China
10.3969/j.issn.1000-8179.2016.10.319
- VernacularTitle:伊马替尼一线治疗慢性粒细胞白血病慢性期患者-单中心十年回顾性分析
- Author:
Fei LI
;
Xiaojie ZHANG
;
Rongyan ZHANG
;
Chengjing XIAO
;
Wei LU
;
Jia RAO
;
Yulan ZHOU
;
Guo'an CHEN
;
Ganping YANG
;
- Publication Type:Journal Article
- Keywords:
imatinib;
chronic myeloid leukemia;
treatment response;
prognosis
- From:
Chinese Journal of Clinical Oncology
2016;43(10):432-437
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Imatinib is extensively used as a first-line therapeutic agent for patients with chronic myeloid leukemia (CML) at the chronic phase (CP). Although CML patients undergoing imatinib treatment are enrolled mainly in the Glivec International Patient Assistance Program (GIPAP) in China since 2003, limited data have been reported on the long-term outcome of these patients. This study aims to compare the treatment response and prognosis of CML-CP patients who received different treatments from January 2003 to December 2013 in the First Affiliated Hospital of Nanchang University. Methods:A total of 295 patients were enrolled, includ-ing 185, 30, 50, and 30 patients for imatinib, interferon-alpha (IFN-α) plus Ara-C, hydroxycarbamide (HU), or allogeneic hematopoietic stem cell transplantation (Allo-HSCT) treatments, respectively. Results:Patients in imatinib and Allo-HSCT groups achieved excellent complete hematologic remission (CHR) (i.e., 96.7%vs. 96.7%), complete cytogenetic response (CCyR) (i.e., 89.7%vs. 93.3%), and com-plete molecular remission (CMoR) (i.e., 49.7%vs. 83.3%, P=0.001). However, significantly low rates of CHR, CCyR, McyR, and CMoR were observed in IFN-αand HU groups. Moreover, patients from imatinib group showed longer overall survival (OS) time than patients from other groups (P<0.001), even patients in Allo-HSCT group (10-year OS, 89.0%vs. 67.0%, P<0.001) because of high risk of Allo-HSCT-related complication. Multivariate analysis showed that receiving imatinib treatment (HR=5.267, 95%CI:1.054-1.940, P=0.022) and achieving CCyR (HR=9.541, 95%CI:1.692-10.513, P=0.002) were independent predictors for OS. Conclusion:Imatinib treatment may be an optimal first-line choice for Chinese patients with CML-CP who have not received any previous treatments.
