Advantage study on utilization of N-terminal pro-B-brain natriuretic peptide for early diagnosis and therapeutic effect monitoring of acute coronary syndrome
10.3969/j.issn.1673-4130.2016.05.020
- VernacularTitle:N-端脑钠素前体应用于急性冠状动脉综合征早期诊断及疗效监控的优势性研究
- Author:
Min′er TANG
- Publication Type:Journal Article
- Keywords:
acute coronary syndrome;
N-terminal pro-B-brain natriuretic peptide;
early diagnosis;
therapeutic effect moni-to ring
- From:
International Journal of Laboratory Medicine
2016;37(5):628-630
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore clinical advantages of N‐terminal pro‐B‐brain natriuretic peptide(NT‐proBNP) in early diagno‐sis and therapeutic effect monitoring of acute coronary syndrome(ACS) .Methods A total of 97 cases of patients with chest pain and obvious discomfort who treated with coronary angiography in this hospital from February to December 2014 were selected .A‐mong these patients ,34 cases with non‐ACS were enrolled in the control group ,while other 63 cases with ACS were divided into the ST‐segment elevation myocardial infarction(STEM ) group ,non‐ST‐segment elevation myocardial infarction(NSTEM ) group and unstable angina pectoris(UA) group .The glycemia ,lipemia ,blood pressure and other indicators were observed .Results The levels of fasting blood‐glucose were within the normal reference interval in all groups ,while levels of lipemia ,plasma NT‐proBNP and blood pressure were higher than the upper limits of normal reference intervals ,and plasma levels of NT‐proBNP were higher than standard of good prognosis(NT‐proBNP<200 pg/mL) .There was statistically significant difference in plasma levels of NT‐proB‐NP among these groups(P<0 .05) ,while no statistically significant differences were found in other indicators among these groups (P>0 .05) .The levels of lipemia and plasma NT‐proBNP and blood pressure were obviously decreased in patients with ACS at each treatment stage .Conclusion NT‐proBNP as a kind of myocardial marker has high accuracy in early diagnosis of ACS ,which could be applied in therapeutic effect monitoring and provide guidance for reasonable selection of treatment strategy .
