Efficacy and safety of intrapleural instillation of Yadanzi (Brucea Javanica)oil emulsion injection and cisplatin for malignant pleural effusion:a meta -analysis
10.3760/cma.j.issn.1008-6706.2016.03.006
- VernacularTitle:鸦胆子油乳注射液联合顺铂腔内注射治疗恶性胸腔积液疗效和安全性评价
- Author:
Huadong CHEN
;
Shangpeng ZHANG
;
Xing′e XU
;
Yanxiao CHEN
;
Rong LOU
;
- Publication Type:Journal Article
- Keywords:
Pleural effusion;
Yadanzi oil emulsion injection;
Cisplatin;
Injection,cavity;
Meta -analysis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(3):341-345
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy and safety of intrapleural instillation of Yadanzi (Brucea Javan-ica)oil emulsion injection and cisplatin for malignant pleural effusion by literature searching and meta -analysis. Methods Databases were searched for random controlled trails (RCTs)including Pubmed,the Cochrane Library, CNKI,VIP,Wanfang Database and CBM.The quality of included RCTs was evaluated and the data were collected by 2 evaluators independently.Meta -analysis was performed using RevMan 5.2.Results 18 RCTs involving 1 322 par-ticipants was included.The results of meta -analysis indicated that intrapleural instillation of Yadanzi oil emulsion injection and cisplatin could improve the treatment efficiency of malignant pleural effusion (OR =3.82,95%CI 2.94 ~4.96,P <0.01)and improve the quality of life of patients(OR =4.07,95%CI 2.87 ~5.79,P <0.01),and reduce the gastrointestinal tract reaction (OR =0.55,95%CI 0.38 ~0.78,P <0.01)and white blood cell reduction occurs (OR =0.34,95%CI 0.25 ~0.46,P <0.01).Conclusion Intrapleural instillation of Yadanzi oil emulsion injection and cisplatin was effective and safe in the treatment of malignant pleural effusion,while the further studies should make efforts in improving research quality.
