Changes of CA125 and PIIINP (Procollagen-3-N-terminal Peptide) in Peritoneal Dialysis Patients with Low GDP Solution.
- Author:
Jeong Yup KIM
1
;
Chang Soo BOO
;
Myung Gyu KIM
;
Gang Ji GO
;
Ji Eun LEE
;
Jin Ho SHIN
;
Young Ju KWON
;
Hui Jeong PYO
Author Information
1. Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea. hjpyo@medimail.co.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
GDP;
Continuous ambulatory peritoneal dialysis;
CA125;
PIIINP
- MeSH:
Dialysis Solutions;
Glucose;
Guanosine Diphosphate*;
Homeostasis;
Hot Temperature;
Humans;
Incidence;
Lactic Acid;
Peritoneal Dialysis*;
Peritoneal Dialysis, Continuous Ambulatory;
Peritonitis;
Prospective Studies;
Sterilization;
Ultrafiltration
- From:Korean Journal of Nephrology
2005;24(1):118-125
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The bioincompatability of the conventional peritoneal dialysis can be partly attributed to the presence of GDPs, which are generated during the heat sterilization. Formation of GDPs can be significantly reduced by the use of multi-chamber bag systems because high concentrated glucose is separated from alkaline lactate. In order to investigate whether multi-chamber bag system can improve the in vivo biocompatibility, we performed a randomized, prospective study comparing the multi-chamber bag system with the conventional PD system, measuring CA125 and PIIINP levels in the effluent dialysates as well as the other clinical and biochemical parameters. METHODS: Forty five patients who were stable on CAPD were enrolled randomly assigned to experiment group (n=27), and control group (n=18). Overnight effluent was collected for measurement of CA125 and PIIINP and the other clinical, biochemical parameters were compared including the number of peritonitis, the ultrafiltration volume. RESULTS: In patients treated with the multiple chamber bag system, there were significantly higher levels of CA125 and PIIINP from 1 month. No clinical and biochemical parameters influenced on their levels. The incidence of peritonitis or ultrafiltration volume did not differ between the two groups. CONCLUSION: Using the low GDP solution resulted in a better preservation of peritoneal mesothelial mass and an improvement of local peritoneal homeostasis, which are supposed to contribute to the biocompatibility of peritoneal dialysis fluid.
