Bile acid induced gut hormones and hepatic glucose metabolism
10.3969/j.issn.1006-6187.2015.12.021
- VernacularTitle:胆汁酸诱导的肠道激素与肝脏糖代谢
- Author:
Hong-wei CAO
;
Wei NG JIA
- Publication Type:Journal Article
- Keywords:
Bile acid;
Fibroblast growth factor 19(FGF19);
Glucagon-like peptides-1(GLP-1);
Liver;
Glucose metabolism
- From:
Chinese Journal of Diabetes
2015;(12):1134-1137
- CountryChina
- Language:Chinese
-
Abstract:
[Summary] Bile acid is a main component of bile ,which plays a key role in keeping cholesterol metabolism balance in vivo and promoting lipids digestion in intestine. Recently ,more and more researches focus on bile acid for its regulating effect on glucose ,lipid and energy metabolism as a signal molecule. The reabsorbed bile acid stimulates the secretion of fibroblast growth factor 19 (FGF19) and glucagon-like peptide-1(GLP-1) in the intestine by activating a nuclear receptor farnesoid X-activated receptor (FXR) and a membrane receptor TGR5. FGF19 and GLP-1 regulate hepatic glucose metabolism through different pathways. Here ,we briefly summarize the research progress and relationship between bile acid induced gut hormones and hepatic glucose metabolism.
