In vitro-in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability
10.1016/j.jpha.2015.02.003
- Author:
Dey Baishakhi
;
Katakam Prakash
;
Assaleh H. Fathi
;
Chandu Rao Babu
;
Adiki Kumari Shanta
;
Mitra Analava
- Publication Type:Journal Article
- Keywords:
Ciprofloxacin;
Analytical methodology;
Bioavailability;
Bio-waiver;
Dissolution study
- From:
Journal of Pharmaceutical Analysis
2015;(6):389-395
- CountryChina
- Language:Chinese
-
Abstract:
Ciprofloxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bioavailability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk. A simple and reliable analytical methodology obtaining a correlation with in vivo urinary excretion studies using UV and HPLC and in vitro dissolution studies (IVIVC) has shown a significant increase in elimination rate of ciprofloxacin co-administered with multivitamins, calcium and milk. Appreciable IVIVC results proved that dissolution studies could serve as an alternative to in vivo bioavailability and also support bio-waivers.