A Case of Idiopathic Light Chain Deposition Disease.
- Author:
Kang Wook LEE
1
;
Han Kyu LEE
;
Young Mo LEE
;
Ki Ryang NA
;
Kwang Sun SUH
;
Young Tai SHIN
Author Information
1. Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.
- Publication Type:Case Report
- Keywords:
Idiopathic light chain deposition disease;
Nephrotic syndrome;
Renal insufficiency
- MeSH:
B-Lymphocytes;
Biopsy;
Bone Marrow;
Capillaries;
Clone Cells;
Cyclophosphamide;
Edema;
Follow-Up Studies;
Immunoglobulin Light Chains;
Lymphoproliferative Disorders;
Multiple Myeloma;
Nephrotic Syndrome;
Paraproteinemias;
Plasma Cells;
Prednisolone;
Proteinuria;
Renal Insufficiency;
Renal Replacement Therapy
- From:Korean Journal of Nephrology
2005;24(1):146-151
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Light chain deposition disease (LCDD) is a systemic disorder characterized by the deposition of monoclonal immunoglobulin light chains (LCs) in various organs. As LCs are overproduced by an abnormal clone of B cells, LCDD is usually described in the course of plasma cell dyscrasias or other lymphoproliferative disorders. However, it can occur in the absence of any detectable hematological disorder even during prolonged follow-up. We experienced a case of 62-year-woman who presented generalized edema, massive proteinuria and renal insufficiency. The histologic findings showed nodular glomerular mesangial expansion and prominent ribbon like immunohistochemical staining for kappa-light chain in the glomerular capillary wall. There was no evidence of multiple myeloma in bone marrow biopsy specimen. Because she refused the intensive chemothrapy, low dose of prednisolone and cyclophosphamide were prescribed for 6 months. Her renal function was maintained relatively well without renal replacement therapy for 7 months. We report a case of idiopathic LCDD not associated with multiple myeloma or other plasma cell dysclasia.
