The Effect of the PDE5 Inhibitor on Noise-induced Hearing Loss

Yuan LIANG; Shujun ZHANG; Xun ZHANG

白话标题:西地那非对噪声性聋豚鼠耳蜗外毛细胞及听功能的影响
作者: Yuan LIANG ; Shujun ZHANG ; Xun ZHANG ;
出版类型:Journal Article
关键字: Sildenafil; Noise-induced hearing loss; Hair cell
来源: Journal of Audiology and Speech Pathology 2015;(6):622-625
国家China
语言:Chinese
摘要: Objective To study the effect of the PDE5 inhibitor on noise-induced hearing loss .Methods 30 guinea pigs were randomly divided into control group ,noise exposure group and PDE5 inbibiter group(10 in each) . Two weeks after white noise exposure of 110 dB ,sildenafil (10 mg?kg -1 ?d-1 ) and NS(4 ml?kg -1 ?d-1 ) were injected into guinea pigs of PDE5 inbibiter group and the noise group respectively .One week after noise exposure four weeks continuous administration was cavried out .The ABR thresholds and the PL of wave Ⅰ were measured respectively prior to the experiment ,1 week post-noise ,1 ,2 and 4 weeks post-drugs .The changes of cochlea hair cells were also observed by light microscopy .Results The ABR threshold shifts and the PL in sildenafil group were less obvious than that of in the noise group .The number of OHCs loss was relatively stable in the normal group , while the obvious OHC loss was observed in other groups .There was significant difference among the three groups , however ,the OHC loss in the sildenafil treatment group was not significantly different from that in the noise expo‐sure (P>0 .05) .Conclusion The inhibitor of PDE5 is able to reduce the decrease of ABR thresholds shift ,shorten the extension of the PL ,and it can significantly protect against noise-induced hearing loss .