cGAS-cGAMP-STING recognizes DNA in inflammatory bowel disease
10.3760/cma.j.issn.1673-4203.2015.07.019
- VernacularTitle:炎症性肠病中cGAS-cGAMP-STING识别病原体DNA的研究进展
- Author:
Song LIU
;
Jian'an REN
- Publication Type:Journal Article
- Keywords:
cGAS;
STING;
Inflammation;
Nucleic acids;
DNA
- From:
International Journal of Surgery
2015;42(7):493-497
- CountryChina
- Language:Chinese
-
Abstract:
Impaired recognition of foreign nucleic acid initiates abnormal mucosal immune responses in intestine.Very little is known on how microbial DNA activates intracellular DNA sensors and controls the function of antigen-presenting cells to shape mucosal immune responses in inflammatory bowel disease (IBD).In current review,we will introduce mucosal dendritic cell population,describe newly identified cGAS-cGAMP-STING complex,and identify certain IBD susceptibility genes that associate with impaired microbial DNA recognition in human.
