The effects of Tianqijiangtang capsule combined with Metformin on the levels of interleukin-6,tumor necrosis factorαand C-reactive protein in patients with type 2 diabetes mellitus

VernacularTitle:天芪降糖胶囊联合二甲双胍对2型糖尿病患者白介素6、肿瘤坏死因子α和C反应蛋白的影响
Author: Yong CAO ; Hong-yu WANG ; Chun XU
Publication Type:Journal Article
Keywords: Tianqijiangtang capsule; Metformin; Interleukin-6 (IL-6); Tumor Necrosis Factor-α(TNF-α); C-reactive protein(C-RP)
From: Chinese Journal of Diabetes 2015;(8):739-741
CountryChina
Language:Chinese
Abstract: Objective To explore the effects of Tianqijiangtang capsule combined with Metformin on the levels of IL‐6 ,TNF‐α and C‐RP protein in patients with T2DM. Methods 80 T2DM were randomized into control group (treatment with Metformin ,n= 40) and treatment group (treatment with Tianqijiangtang in combination with Metformin ,n=40). The changes of levels of IL‐6 ,TNF‐α and C‐RP were observed before and after the treatment. Results Compared to the pretreatment in the same group and after treatment in control group ,IL‐6 ,TNF‐αand C‐RP of treatment group were reduced significantly [(6.79 ± 0.60) ,(7.15 ± 0.62) vs (5.08 ± 0.43)pg/ml;(8.94 ± 0.55) ,(8.61 ± 0.66) vs (5.18 ± 0.45) pg/ml;(6.79 ± 0.60) ,(6.58 ± 0.59) vs (5.56 ± 0.30) mg/L ,P<0.01]. Conclusion Tianqijiangtang capsule combined with Metformin can decrease the levels of IL‐6 ,TNF‐αand C‐RP in T2DM patients.