Expression of leucine-rich and immunoglobulin-like domains 1 and epidermal growth factor receptor and their significance in cervical adenocarcinoma
10.3760/cma.j.issn.1006-9801.2014.12.015
- VernacularTitle:多亮氨酸重复区免疫球蛋白样蛋白1及表皮生长因子受体在子宫颈腺癌组织中的表达及其意义
- Author:
Yu WANG
;
Yang DENG
;
Xiumei WANG
;
Xi'an LU
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Leucine-rich and immunoglobulin-like domains1;
Receptor,epidermal growth factor;
Immunohistochemistry
- From:
Cancer Research and Clinic
2014;26(12):843-846
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and prognostic significance of leucine-rich and immunoglobulin-like domains 1 (LRIG1) and epidermal growth factor receptor (EGFR) in cervical adenocarcinoma.Methods The expression levels of LRIG1 and EGFR were assayed by immunohistochemistry in 47 cervical adenocarcinoma,24 cervical glandular intraepithelial neoplasia (CGIN) and 60 normal cervical tissues.Results The expression rates of LRIG1 in cervical adenocarcinoma,CGIN and normal cervical tissues were 21.28 ％ (10/47),29.17 ％ (7/24) and 83.33 ％ (50/60),respectively,the expression of EGFR in cervical adenocarcinoma,CGIN and normal cervical tissues were 82.98 ％ (39/47),45.83 ％ (11/24),5.00 ％ (3/60),respectively.The expression of LRIG1 was not correlated to age (P ＞ 0.05).However,it was correlated to histological grade,lymphatic nodes metastasis and clinical stages (all P ＜ 0.05).The survival rate of positive LRIG1 patients was higher than that of negative LRIG1 patients (P ＜ 0.05).Conclusions LRIG1 may play an important role in predicting clinical outcomes of cervical adenocarcinoma,and its mechanism may be related to inhibiting EGFR signal transduction.
