Clinical characteristics of 21 patients with mycosis fungoides

VernacularTitle:蕈样肉芽肿21例临床特征分析
Author: Xiao-bing HUANG ; Jing-lin NG ZHA ; Xiao-dong WANG ; Chun-sen WANG
Publication Type:Journal Article
Keywords: Mycosis fungoides; Clinical analysis
From: Journal of Leukemia & Lymphoma 2009;18(10):612-615
CountryChina
Language:Chinese
Abstract: Objective To improve the understand of the clinical characteristics of mycosis fungoides and provide guidance for the clinical work. Methods The clinical data of 21 patients with mycosis fungoides in our hospital were retrospectively analyzed including the ages at diagnosis, clinicopatholagic characteristics of skin lesions, systemic manifestation, misdiagnosis and treatment of these patients. Results The mean age was (57.3±2.31) years at the diagnosis. Most patients were at the stage of plaques. Clinical manifestations included generalized lesions (52.4 %) and itchy (66.7 %). Epidermotropism (66.7 %) and pautriers microabscesses(57.1%) were common histopathologic features. Previous misdiaguosis rate was 66.7 %. Skin targeted therapies and biologic therapies were effective approaches to relieve the skin rash at early stage, and combined chemotherapy was typically applied in more advanced cases. Conclusion Mycosis fungoides has various clinical characteristics and careful differential diagnosis should be made in clinical practice.