Myoblast transplantation for heart repair: A review of the state of the field
- Author:
Leonhardt J. Howard
;
Brown Michael
- Publication Type:Journal Article
- Keywords:
myoblast transplantation;
heart failure
- From:Journal of Geriatric Cardiology
2006;3(3):165-167
- CountryChina
- Language:Chinese
-
Abstract:
Over 200 humans have been treated with myoblast transplantation for heart muscle repair since June 2000. Bioheart sponsored percutaneous delivery studies began in May 2001 in Europe. Approximately one third of the patients have exhibited substantial improvement in left ventricular ejection fraction (LVEF) of over 30% and two heart failure class improvements. Over 80% of the patients have exhibited one heart failure class improvement with moderate improvement of LVEF. Clinical trials seem to demonstrate a marked reduction in emergency hospitalizations in myoblast treated patients. Many years of careful studies have lead to randomized controlled studies that are enrolling patients now at numerous centers worldwide. A firm conclusion on the safety and efficacy of myoblast transplantation cannot be determined until these randomized studies are completed. Final results from randomized controlled studies should be available soon. (J Geriatr Cardiol 2006;3:165-7.)
