Mechanisms of proteasome inhibitor bortezomib on the therapy of multiple myeloma
10.3760/cma.j.issn.1009-9921.2011.11.020
- VernacularTitle:蛋白酶体抑制剂硼替佐米治疗多发性骨髓瘤的分子机制
- Author:
Na ZHAO
;
Jun-jie NG YA
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Proteasome inhibitor,Bortezomib;
Therapy
- From:
Journal of Leukemia & Lymphoma
2011;20(11):698-700
- CountryChina
- Language:Chinese
-
Abstract:
The ubiquitin-proteasome pathway is one of important pathways during selective protein degradation,which participates in many intracellular physiological and biochemical processes.Bortezomib,a kind of proteasome inhibitor,can inhibit cell growth and proliferation,induce cell apoptosis and overcome drug resistance in chemotherapy.The mechanisms of bortezomib on the therapy of multiple myeloma are reviewed in this paper.
