Voltammetric behavior of sedative drug midazolam at glassy carbon electrode in solubilized systems
10.1016/j.jpha.2011.11.008
- Author:
Jain Rajeev
;
Yadav Kumar Rajeev
- Publication Type:Journal Article
- Keywords:
Midazolam;
Voltammetry;
Surfactant;
Glassy carbon electrode;
Parenteral dosage form
- From:
Journal of Pharmaceutical Analysis
2012;02(2):123-129
- CountryChina
- Language:Chinese
-
Abstract:
Redox behavior of midazolam was studied at a glassy carbon electrode in various buffer systems,supporting electrolytes and pH using differential paise,square-wave and cyclic voltammetry.Based on its reduction behavior,a direct differential pulse voltammetric method has been developed and validated for the determination of midazolam in parenteral dosage.Three welldefined peaks were observed in 0.1％ SLS,Britton-Robinson (BR) buffer of pH 2.5.The effect of surfaetants like sodium lauryl sulfate (SLS),cetyl trimethyl ammonium bromide (CTAB) and Tween 20 was studied.Among these surfactants SLS showed significant enhancement in reduction peak.The cathodic peak currents were directly proportional to the concentration of midazolam with correlation coetfficient of 0.99.
