Effect of docetaxel-loaded lipid microbubbles combined with ultrasound targeted microbubbles destruction on microvessel of rabbit VX2 liver tumor models
- VernacularTitle:载多西紫杉醇脂质微泡联合超声靶向微泡破裂对兔VX2肝癌微血管的作用
- Author:
Juan KANG
;
Xiao-ling WU
;
Yong ZHANG
;
Hai-tao RAN
;
Zhi-gang WANG
- Publication Type:Journal Article
- Keywords:
Docetaxel;
Microbubble;
Microvessel;
Rabbits;
Liver neoplasms
- From:
Chinese Journal of Interventional Imaging and Therapy
2011;08(5):431-434
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the inhibition effect of docetaxel-loaded lipid microbubbles (DLLM) combined with ultrasound targeted microbubbles destruction (UTMD) on microvessel in rabbit VX2 liver tumor models.MethodsSixty rabbits were randomly divided into 6 groups (n= 10),i.e.Doc group (used docetaxel only),DLLM group (used docetaxel-loaded lipid microbubbles),Doc+US group (used docetaxel combined with ultrasound positioning irradiation),PLM+US group (used microbubbles combined with ultrasound positioning irradiation),DLLM+US group (used docetaxel-loaded lipid microbubbles combined with ultrasound positioning irradiation) and control group.The expression of CD34 and VEGF and microvessel density (MVD) were compared among different groups.ResultsAfter treatment,the expression of CD34 in DLLM+US group was lower,the MVD of DLLM+US group was markedly lower than that of the other groups (P＜0.01),while the expression of VEGF in this group was the lowest among all 6 groups (P＜ 0.01).ConclusionDLLM combined with UTMD can inhibit the generation of microvessels in rabbit VX2 liver tumor,thus inhibit the growth of the tumor.
