Locally advanced prostate cancer: combination of high-dose high-precision radiotherapy and androgen deprivation therapy
10.3760/cma.j.issn.1004-4221.2014.06.001
- VernacularTitle:Locally advanced prostate cancer:combination of high-dose high-precision radiotherapy and androgen deprivation therapy
- Author:
Bolla Michel
;
Mirimanoff René-Olivier
- Publication Type:Journal Article
- From:
Chinese Journal of Radiation Oncology
2014;23(6):463-467
- CountryChina
- Language:Chinese
-
Abstract:
Locally advanced prostate cancer entails a risk of local,regional and systemic relapse requiring the combination of a Ioco-regional treatment,namely external beam radiotherapy(EBRT) to control the pelvic-confined disease,combined with a systemic therapy,namely androgen-deprivation therapy(ADT),to potentiate irradiation and to destroy the infra-clinical androgen-dependant disease outside the irradiated volume.Many phases Ⅲ randomized trials have paved the way in establishing the indications of this combined approach,which requires a long term ADT(≥2 years) with LHRH agonists.The duration of ADT may be reduced to 6 months should there be a significant comorbidity,a reluctance from the patient or a poor tolerance.A multidisciplinary approach will enable physicians to tailor the treatment strategy and a close cooperation between the specialists and the general practitioners will be set up to prevent as much as possible the side-effects of ADT.
