Impact of the signal path PD-1/PD-L1 on Treg cells and tumor cells
10.3760/cma.j.issn.1673-422X.2014.11.003
- VernacularTitle:程序性凋亡分子1及其配体信号通道对调节性T淋巴细胞及肿瘤细胞的影响
- Author:
Shu'an SONG
;
Daxun PIAO
;
Tao JIANG
;
Qiongyou JING
;
Jianbing WANG
;
- Publication Type:Journal Article
- Keywords:
Neoplasms;
T-lymphocytes;
Tumor escape;
Programmed cell death 1 receptor
- From:
Journal of International Oncology
2014;41(11):808-810
- CountryChina
- Language:Chinese
-
Abstract:
Programmed death-1 (PD-1) and its ligand PD-L1 are the major members of inhibitory costimulatory molecules and express high in a variety of tumor cells and their associated cells surface,while the proportion of regulatory T cells (Tregs) are abnormally elevated in tumor infiltrating T lymphocytes cells.PD-L1 combined with PD-1 and Treg help tumors evade immune clearance,weaken immune responses and induce immune tolerance.New researches find that PD-L1 plays an important role in the development and function maintenance of inducible Treg (iTreg),and PD-L1 signal can change initial CD4 + CD25-T cells into iTreg to play a role of immunosuppression.Research on PD-1 signaling pathway can provide a new theoretical basis for the inhibition of tumor immune escape in clinical application of immunotherapy and better treatments.
