Bioinformatics Analysis on Molecular Network and Bio-function ofBu-Fei-Yi- Shen Decoction
10.11842/wst.2015.04.004
- VernacularTitle:基于生物信息学方法探析补肺益肾方的分子网络及生物功能
- Author:
Li LI
;
Suxiang FENG
;
Jing'an BAI
;
Miao JIANG
;
Cheng LV
;
Hongtao GUO
;
Jiansheng LI
;
Aiping LV
- Publication Type:Journal Article
- Keywords:
Bu-Fei-Yi-Shen decoction;
target protein;
IPA;
PubChem
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;17(4):773-778
- CountryChina
- Language:Chinese
-
Abstract:
This article was aimed to study the molecular network and bio-function ofBu-Fei-Yi-Shen (BFYS) decoction for chronic obstructive pulmonary disease (COPD) by bioinformatics analysis, in order to provide new ideas for research on pharmacological mechanism of Chinese medicine compound prescription. Components of herbs in BFYS decoction were searched in the databases. Targeted proteins of each component were found from PubChem. Comparison analyses were performed on molecular network, bio-function and canonical pathways by Ingenuity Pathway Analysis (IPA). The results showed that there were 239 target proteins of BFYS decoction. There were 9 molecular networks of BFYS decoction. The top 3 networks' functions were Cellular Development, Energy Production, and Cancer. The top 3 bio-function of BFYS decoction were Cellular Growth and Proliferation, Cell Death and Survival, and Inflammatory Response. The top 3 canonical pathways of BFYS decoction were Cell Cycle:G1/S Checkpoint Regulation, Chronic Myeloid Leukemia Signaling, and Cyclins and Cell Cycle Regulation. It was concluded that the search of target proteins for herbal compounds and bioinformatics analysis by IPA can be used to reveal the molecular network and bio-function of BFYS decoction.
