Clinical study on changes of indexes of hemorheology and inflammatory factors of fasudil intervention on acute myocardial infarction

VernacularTitle:盐酸法舒地尔对急性心肌梗死患者血液流变学和血清炎性细胞因子的影响研究
Author: Ling HUANG ; Zhen ZHANG ; Zhuo'er WANG ; Jianfei ZHOU ;
Publication Type:Journal Article
Keywords: Myocardial infarction; Fasudil; Hemorheology; Inflammatory factors
From: Chinese Journal of Primary Medicine and Pharmacy 2015;(11):1689-1692
CountryChina
Language:Chinese
Abstract: Objective To investigate the possible mechanisms of fasudil on acute myocardial infarction (AMI)by observing the changes of hemorheology and inflammatory factors.Methods 120 patients diagnosed AMI in our hospital were randomly divided into the two groups:60 cases in the control group were given the conventional treat-ment and the other 60 cases in the treatment group were added fasudil for 2 weeks based on that.Then we analyzed the changes of hemorheology and inflammatory factors.Results 2 weeks later,the whole blood restore viscosity,plasma viscosity,CRP,IL -1β,IL -6 and TNF -βin the two groups were all obviously decreased than those of before(P <0.05),while,packed cell volume in the treatment group was obviously decreased as well (P <0.05).Furthermore, the changes in the treatment group were more significant compared with the controlled group (P <0.05).Conclusion Fasudil intervention on AMI can improve the situation of hemorheology and relieve the inflammation more effectively than conventional treatment.