Cognition, Emotion and Social Function: Are Vulnerability Markers for Developing Schizophrenia?.
- Author:
Kyung Jin LEE
1
;
Whee WEE
;
So Young YOO
;
Ae Ra LEE
;
Ji Yeon SONG
;
Tae Hyun HA
;
Kyung Sue HONG
;
Myung Sun KIM
;
Jun Soo KWON
Author Information
1. Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU-MRC, Seoul, Korea. Kwonjs@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Genetic high risk;
Neurocognitive function;
Selective attention;
Recall memory;
Independence-performance;
Independence-competence;
Emotion control
- MeSH:
Cognition*;
Humans;
Memory;
Schizophrenia*
- From:Journal of Korean Neuropsychiatric Association
2006;45(1):3-10
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Vulnerability marker in biological relatives of schizophrenia may be very useful in identifying the propensity for the development of schizophrenia. This study suggests that the relatives at risk for genetically developing schizophrenia have impairments in several domains of cognition, social function and affective function as a vulnerability marker. METHODS: A neurocognitve function test, a social function test and an affective function test were administered to fifteen healthy relatives from families with two or more patients with schizophrenia (geneticallly high risk subjects). Fifteen healthy controls matched for age and gender were recruited in this study. RESULTS: Compared to the control subject, the genetic high risk subjects performed significantly more poorly in the selective attention and recall memory of neurocognitive function. The high risk subjects also had lower scores in independence-performance and independence-competence of the social function test and emotion control of the affective function test. CONCLUSION: Selective attention, recall memory, independence-performance, independence-competence and emotion control ability may be a valuable marker for genetic study of schizophrenia.
