Investigating the dose-response curves of cisatracurium in the different gender epileptics
- VernacularTitle:不同性别癫痫患者顺式阿曲库铵剂量-反应曲线的测定
- Author:
Zhong-jie LIU
;
Qing-guo ZHANG
;
Le LI
;
Ai-zhu LU
;
Lu-ying LAI
;
Shi-yuan XU
- Publication Type:Journal Article
- Keywords:
Sex;
Epilepsy;
Cisatracurium;
Dose-response curve
- From:
The Journal of Clinical Anesthesiology
2014;(12):1202-1204
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the gender differences in dose-response curve with cisatra-curium in epileptics.Methods Eighty ASA grade Ⅰ or Ⅱ epileptics were enrolled in this study.All patients were divided into male and the female groups and received the method of single dose injection under midazolam-fentanyl intravenous anesthesia.Each patient received intravenous bolus of 20,30, 40,50μg/kg of cisatracurium respectively.The neuromuscular block was measured by Neuromuscular Transmission Monitor and the responses were defined in terms of the percentages of maximum sup-pression in T1 of TOF of the adductor pollicis muscle.According to log-probit transformation of the data of dose and response,the dose-response curve of cisatracurium was established through linear re-gression.The onset time of cisatracurium was also observed.Results The ED50 ,ED75 ,ED90 ,ED95 values of cisatracurium in male epilepsy patients were 37.2±9.7,48.1±11.3,60.4±12.8,69.3± 14.0 μg/kg and that of female epilepsy patients were 36.6±4.3,47.5±7.7,60.5±14.0,70.1± 19.4 μg/kg.There was no significant difference between the two gender groups.No significant change in onset time was observed among 4 dose groups.Conclusion No gender differences are ob-served in dose-response curve of cisatracurium in epileptics.
