Correlation analysis between growth differentiation factor-15 and ventricular remodeling indexes after myocar-dial infarction
10.3969/j.issn.1008-0074.2014.04.14
- VernacularTitle:GDF-15与心肌梗死后心室重塑指标的相关性分析
- Author:
Can-jun LIU
;
- Publication Type:Journal Article
- Keywords:
Heart failure,congestive;
Ventricular remodeling;
Fibrosis
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(4):408-411
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore change of serum level of growth differentiation factor-15 (GDF-15)in patients with heart failure (HF)after myocardial infarction,and its correlation with cardiac function and myocardial fibrosis indexes.Methods:A total of 100 HF patients after acute myocardial infarction (AMI)were enrolled as HF group,and 50 healthy subjects were selected as healthy control group.GDF-15 level change was measured,its correlation with cardiac function [left ven-tricular end-systolic diameter (LVESd),left ventricular end-diastolic diameter (LVEDd)and left ventricular ejection frac-tion (LVEF)]and relative indexes of myocardial fibrosis [brain natriuretic peptide (BNP),serum transforming growth fac-tor (TGFβ),type I and III procollagen amino-terminal peptides (PINP,PIIINP)]were analyzed in two groups.Results:Compared with healthy control group,there were significant rise in serum levels of GDF-15 [(623.56±70.21)ng/L vs. (2003.53±163.2)ng/L],TGFβ[(21.5±6.89)ng/ml vs.(58.93±12.81)ng/ml],PINP [(150.58±32.57)ng/ml vs. (233.15±26.94)ng/ml]and PIIINP [(17.56±8.72)ng/ml vs.(48.64±9.28)ng/ml]in HF group,P <0.05~<0.01. Along with NYHA cardiac function class increased (II~IV),GDF-15 level significantly elevated [(1521.32±98.23)ng/L vs.(2311.92±108.52)ng/L vs.(3023.54±129.36)ng/L,P <0.01 all].Pearson correlation analysis indicated that in HF patients after myocardial infarction,serum GDF-15 level was inversely correlated with LVEF (r =-0.574,P <0.05), and positively correlated with LVESd and LVEDd (r =0.688,0.752,P <0.05 both);GDF-15 level was positively correla-ted with plasma BNP level,serum levels of PINP,PIIINP and TGFβ(r =0.568~0.82,P <0.05 all).Conclusion:Growth differentiation factor-15 is involved in ventricular remodeling in patients with heart failure after myocardial infarction.
