Prognostic value of NT-proBNP in patients with non ST elevation myocardial infarction
10.3969/j.issn.1008-0074.2014.04.11
- VernacularTitle:血浆氨基末端脑钠肽前体对 NSTEMI 患者预后评估的价值
- Author:
Zheng-jun QI
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Natriuretic peptide,brain;
Prognosis
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(4):398-400
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the prognostic value of N-terminal pro brain natriuretic peptide (NT-proBNP)as-sessing prognosis in patients with non ST elevation myocardial infarction (NSTEMI).Methods:Clinical and follow-up data of 96 NSTEMI inpatients from our hospital were retrospectively analyzed.According to their outcomes, they were divided into no event group [n=46,no major adverse cardiovascular events (MACE)occurred]and event group (n=50,MACE occurred).Levels of NT-proBNP,total cholesterol (TC)and low density lipoprotein choles-terol (LDL-C),left ventricular end-diastolic diameter (LVEDd),mitral early/late diastolic peak flow velocity (E/A)and left ventricular ejection fraction (LVEF)were measured and compared between two groups.Single-factor linear analysis and multivariate Logistic regression analysis were used to analyze relative factors of MACE incidence rate,ROC curve was used to analyze the best predictive value of NT-proBNP.Results:Compared with no event group,there were significant rise in NT-proBNP level [(3157.5±102.4)pmol/L vs.(4309.6±214.6)pmol/L]and LVEDd [(58.1±5.5)mm vs.(74.3±6.8)mm];and significant reduction in LVEF [(71.8±4.1)% vs.(49.5 ±3.9)%]and E/A [(0.84±0.18)vs.(0.62±0.12)]in event group (P <0.05 all).There were no significant difference in TC and LDL-C levels between two groups (P >0.05 both).Multivariate Logistic regression analysis in-dicated that NT-proBNP was an independent predictor for MACE (OR=1.003,P =0.009).Survival rate of those with plasma NT-proBNP≤4390 pmol/L was significantly higher than those with NT-proBNP >4390 pmol/L (OR=5.028,P =0.021).Conclusion:Plasma N-terminal pro brain natriuretic peptide can independently predict progno-sis of patients with non ST elevation myocardial infarction.
