A Meta-analysis of ibuprofen and indomethacin in the treatment of infants patent ductus arteriosus

VernacularTitle:布洛芬及吲哚美辛治疗婴儿动脉导管未闭的 Meta分析
Author: Qiongfang YANG
Publication Type:Journal Article
Keywords: patent ductus arteriosus; ibuprofen; indomethacin; Meta-analysis; infants
From: Chongqing Medicine 2014;(24):3176-3179
CountryChina
Language:Chinese
Abstract: Objective This study to investigate the safety and efficacy of ibuprofen versus indomethacin in infants treated for pa-tent ductus arteriosus .Methods Comprehensive search different databases about randomized controlled study of ibuprofen and in-domethacin treatment of patent ductus arteriosus ,screening qualified literature ,Meta-analysis of the research results ,and to analysis the efficacy of the PDA ,necrotizing enterocolitis ,produce urine ,renal function .Results 17 articles were included .Meta-analysis re-sults showed that PDA closure rate of ibuprofen versus indomethacin no significant difference [95% CI:0 .97-1 .10 ,P=0 .34] ,but oliguria in the ibuprofen group was significantly less than the indomethacin group and the effect on renal function in children less than indomethacin .Other side effect was no significant difference(P>0 .05) .Conclusion Ibuprofen for PDA closure appears to be as effective as indomethacin .The NEC generated no significant difference ,but the side effects of ibuprofen on the kidneys is signifi-cantly less than indomethacin ,so ibuprofen is more suitable for use in the clinical treatment of PDA .