Oleanolic acid isolated from ethanolic extract of Phytolacca decandra induces apoptosis in A375 skin melanoma cells: drug-DNA interaction and signaling cascade.
- Author:
Ghosh, Samrat
;
Bishayee, Kausik
;
Khuda-Bukhsh, Anisur Rahman
- Publication Type:Journal Article
- From:
Journal of Integrative Medicine
2014;12(2):102-14
- CountryChina
- Language:English
-
Abstract:
Oleanolic acid (OA) has been reported to have anticancer effects, but the extent of its cytotoxicity, its ability to interact with nuclear DNA, its action against skin melanoma, as well as the molecular mechanism of its action against cell proliferation and in support of cell death are still unexplored. This led us to examine the efficacy of OA, a bioactive compound isolated from Phytolacca decandra, on these issues in the present investigation.
