Retinoblastoma.
- Author:
Hong Joo HAN
1
;
Byung Il PARK
Author Information
- Publication Type:Original Article
- MeSH: Diagnosis; Female; Follow-Up Studies; Humans; Male; Penetrance; Retinoblastoma*; Siblings
- From:Journal of the Korean Ophthalmological Society 1970;11(4):59-65
- CountryRepublic of Korea
- Language:Korean
- Abstract: Retinoblastoma has been established as an inheritable disease. To the development of sporadic cases the mutation can be ascrivable. Once the gene has been established, however, it is transmitted as an autosomal dominant characteristics with incomplete penetrance. The cases reported here was established in siblings which are of the extremely rare entities. Two families are reported here, which is one of the rare occurence. 1st. Family: The retinoblastoma affect 4 siblings(male, 2. female, 2) in 8 siblings(male, 3. female, 5). Of this 4 cases, 3 died of progression of retinoblastoma, while the one left was in apparent good health with early enucleation. 2 nd. family: Retinoblastoma existed in two siblings(male, 1. female, 1). The male dead 1 year after diagnosis of retinoblastoma and the other one refused radical treatment and lost in follow up.
