Influence of surgery on the regulatory T cell levels in peripheral blood for patients with cavitary tuberculosis
10.3760/cma.j.issn.1008-6706.2014.09.006
- VernacularTitle:手术对空洞型肺结核患者外周血调节性T细胞水平的影响
- Author:
Yin′e WU
;
Wenguang PENG
;
Qinghua WU
;
Gaozhe ZHENG
;
Shiyang LIN
- Publication Type:Journal Article
- Keywords:
Tuberculosis,Pulmonary;
Pulmonary Surgical Procedures;
T-Lymphocytes,Regulatory
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(9):1292-1293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the regulatory T cell ( CD4 +CD25 +FoxP3 +T) levels in peripheral blood of patients with cavitary tuberculosis before and after surgery .Methods We compared the proportion of CD4 +CD25high T cells and CD4 +CD25 +FoxP3 +T cells in 13 patients with cavity tuberculosis pre-and post-operatively and in 10 healthy control subjects with flow cytometry .Results (1) The proportion of CD4 +CD25high T cells and CD4 +CD25 +FoxP3 +T cells were significantly higher in patients with cavity tuberculosis and at 1-month postoperatively than that in healthy controls(P<0.01).The proportion of CD4 +CD25high T cells and CD4 +CD25 +FoxP3 +T cells had no statistical significance between the patients with cavity tuberculosis at 6-months postoperatively and healthy controls (P>0.05).(2)The proportion of CD4 +CD25high T cells and CD4 +CD25 +FoxP3 +T cells decreased significantly af-ter 6 months surgery than preoperatively in patients with cavity tuberculosis (P<0.01).(3)Pre-and post-operative proportions of CD4 +CD25high T cells and CD4 +CD25 +FoxP3 +T cells showed a positive correlation ( r=0.878,P<0.01 ) .Conclusion The proportion of the circulating T regulatory cells increases in patients with cavity tuberculosis , and decreases after surgery .Infection with M.tuberculosis may induce regulatory T cell-surface molecular changes.
